期刊
MARINE DRUGS
卷 17, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/md17090516
关键词
Talaromyces verruculosus; oligophenalenone dimers; soft coral-derived fungus; secondary metabolites
资金
- Scientific Research Foundation of Third Institute of Oceanography, Ministry of Natural Resources [2016008, 2016006]
- Fujian Provincial Natural Science Foundation [2018J05142, 2017J01146]
- National Natural Science Foundation of China [81603145, 81901133]
In an effort to discover new bioactive anti-tumor lead compounds, a specific tyrosine phosphatase CDC25B and an Erb family receptor EGFR were selected as drug screening targets. This work led to the investigation of the soft coral-derived fungus Talaromyces verruculosus and identification of two new oligophenalenone dimers, verruculosins A-B (1-2), along with three known analogues, bacillisporin F (3), duclauxin (4), and xenoclauxin (5). Compound 1 was the first structure of the oligophenalenone dimer possessing a unique octacyclic skeleton. The detailed structures and absolute configurations of the new compounds were elucidated on the basis of spectroscopic data, X-ray crystallography, optical rotation, Electronic Circular Dichroism (ECD) analysis, and nuclear magnetic resonance (NMR) calculations. Among which, compounds 1, 3, and 5 exhibited modest inhibitory activity against CDC25B with IC50 values of 0.38 +/- 0.03, 0.40 +/- 0.02, and 0.26 +/- 0.06 mu M, respectively.
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