4.7 Article

Echinochrome A Attenuates Cerebral Ischemic Injury through Regulation of Cell Survival after Middle Cerebral Artery Occlusion in Rat

期刊

MARINE DRUGS
卷 17, 期 9, 页码 -

出版社

MDPI
DOI: 10.3390/md17090501

关键词

echinochrome A; brain ischemic stroke; cell survival

资金

  1. Basic Science Research Program through the National Research Foundation of Korea (NRF) - Korea government (MSIT) [2018R1A2B6003158]
  2. Bio and Medical Technology Development Program of the National Research Foundation (NRF) - Ministry of Science and ICT [NRF-2017M3A9G7072568]
  3. Ministry of Science and Higher Education of the Russian Federation [RFMEFI61317X0076]
  4. National Research Foundation of Korea [2018R1A2B6003158] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

向作者/读者索取更多资源

Of late, researchers have taken interest in alternative medicines for the treatment of brain ischemic stroke, where full recovery is rarely seen despite advanced medical technologies. Due to its antioxidant activity, Echinochrome A (Ech A), a natural compound found in sea urchins, has acquired attention as an alternative clinical trial source for the treatment of ischemic stroke. The current study demonstrates considerable potential of Ech A as a medication for cerebral ischemic injury. To confirm the effects of Ech A on the recovery of the injured region and behavioral decline, Ech A was administered through the external carotid artery in a rat middle cerebral artery occlusion model after reperfusion. The expression level of cell viability-related factors was also examined to confirm the mechanism of brain physiological restoration. Based on the results obtained, we propose that Ech A ameliorates the physiological deterioration by its antioxidant effect which plays a protective role against cell death, subsequent to post cerebral ischemic stroke.

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