期刊
LIPIDS
卷 55, 期 1, 页码 23-33出版社
WILEY
DOI: 10.1002/lipd.12189
关键词
High-fat diet; Mouse; Short-term; Skin; Wound healing
资金
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Fundacao de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- CAPES
High intake of dietary fat plays an important role in obesity development in animals and humans, and prolonged intake of high-fat diet might lead to low-grade chronic inflammation. Previous study showed that diet-induced overweight delays cutaneous wound healing in both obesity-prone and obesity-resistant animals, highlighting the importance of diet composition in the wound healing process. This study evaluated the hypothesis that a short-term administration of high-fat diet could affect cutaneous wound healing. Male mice (C57/bl6) were randomly divided into standard (10% energy from fat) or high-fat (60% energy from fat) chow groups. After 10 days of diet administration, an excisional lesion was performed and the animals were sacrificed 6 or 10 days later. There was no difference in the fasting blood glucose between groups. Ten days after wounding, high-fat chow group presented increased inflammatory infiltrate, levels of inducible nitric oxide synthase and cyclo-oxygenase-2 proteins, and lipid peroxidation. The high-fat chow group presented delayed wound closure, increased amount of myofibroblasts and vessels, and decreased deposition of type I collagen. These findings support the hypothesis that short-term administration of high-fat diet exerts negative effects on mice cutaneous wound healing, due to the interference in the inflammatory phase.
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