期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 141, 期 43, 页码 17048-17052出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.9b07193
关键词
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资金
- SNF [200020_182046]
- ERC [694424]
- European Molecual Biology Organisation [ALTF-194-2017]
- European Research Council (ERC) [694424] Funding Source: European Research Council (ERC)
Bioorthogonal uncaging reactions offer versatile tools in chemical biology. In recent years, reactions have been developed to proceed efficiently under physiological conditions. We present herein an uncaging reaction that results from ring-closing metathesis (RCM). A caged molecule, tethered to a diolefinic substrate, is released via spontaneous 1,4-elimination following RCM. Using this strategy, which we term close-to-release, we show that drugs and fluorescent probes are uncaged with fast rates, including in the presence of mammalian cells or in the periplasm of Escherichia coli. We envision that this tool may find applications in chemical biology, bioengineering and medicine.
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