期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 141, 期 43, 页码 17198-17206出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.9b07763
关键词
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资金
- DFG (Gottfried-Wilhelm-Leibniz award)
A flow-metallaelectro-catalyzed C-H activation was realized in terms of robust rhodaelectro-catalyzed alkyne annulations. To this end, a modular electro-flow cell with a porous graphite felt anode was designed to ensure efficient turnover. Thereby, a variety of C-H/N-H functionalizations proved amenable for alkyne annulations with high levels of regioselectivity and functional group tolerance, viable in both an inter- or intramolecular manner. The electro-flow C-H activation allowed easy scale up, while in-operando kinetic analysis was accomplished by online flow-NMR spectroscopy. Mechanistic studies suggest an oxidatively induced reductive elimination pathway on rhodium(III) in an electrocatalytic regime.
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