期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 141, 期 38, 页码 15024-15028出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.9b08659
关键词
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资金
- National Science Foundation [CHE 1361654]
- NIH (NIGMS) [R01-077379, R01-131713]
- SERB
- IUSSTF
- Mellichamp Academic Initiative in Sustainability at UCSB
Direct enantioselective alpha-alkylation of 2-alkylpyridines provides access to chiral pyridines via an operationally simple protocol that obviates the need for prefunctionalization or preactivation of the substrate. The alkylation is accomplished using chiral lithium amides as noncovalent stereodirecting auxiliaries. Crystallographic and solution NMR studies provide insight into the structure of well-defined chiral aggregates in which a lithium amide reagent directs asymmetric alkylation.
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