期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 141, 期 40, 页码 15730-15736出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.9b07251
关键词
-
资金
- Mississippi State University Office of Research and Economic Development and Department of Chemistry
Ru(II)-catalyzed enantioselective C-H activation/hydroarylation has been developed for the first time, allowing for highly enantioselective synthesis of indoline derivatives via catalytic C-H activation. Commercially available Ru(II) arene complexes and chiral alpha-methylamines were employed as highly enantioselective catalysts. Based on a sterically rigidified chiral transient directing group, multisubstituted indolines were produced in up to 92% yield with 96% ee. Further transformation of the resulting 4-formylindoline enables access to an optically active tricyclic compound that is of potential biological and pharmaceutical interest.
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