期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 25, 期 11, 页码 2353-2355出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2015.04.022
关键词
Sinularia sandensis; Sesquiterpenoid; Cytotoxicity; Antiviral activity; HCMV (human cytomegalovirus)
资金
- Ministry of Science and Technology - Taiwan [NSC-102-2320-B-110-003-MY3, NSC-102-2113-M-390-001]
- NSYSUKMU Joint Project [NSYSUKMU-104-P023]
A chromatographic and NMR spectroscopy-based fractionation on the acetone extracts of the soft coral Sinularia sandensis led to the isolation of a novel sesquiterpenoid, sandensone A (1). The structure of 1 was elucidated based on comprehensive 1D and 2D NMR spectroscopic data as well as HRESIMS spectrometry. The absolute configuration at C-12 of 1 was determined as R using a modified Mosher's method. The cytotoxicity against A549 (human lung carcinoma), HT-29 (human colon adenocarcinoma), and P-388 (mouse lymphocytic leukemia) cancer cell lines as well as antiviral activity against HCMV (human cytomegalovirus) were evaluated in vitro. (C) 2015 Elsevier Ltd. All rights reserved.
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