Environmental friendly synthesis of silver nanomaterials from the promising Streptomyces parvus strain Al-Dhabi-91 recovered from the Saudi Arabian marine regions for antimicrobial and antioxidant properties

The therapeutic molecules recovered from the marine biological origin are widely used for the treatment of diverse levels of infections caused by microbial pathogens. In addition, the eco-friendly preparations of nano materials together with the secondary metabolites' producing active microbial strains effectively suppress the spreading of the pathogenic bacteria. Considering their importance, the present study evaluated the environmental friendly synthesis of Silver nitrate nanomaterials (SNM) from the active marine Streptomyces strain Al-Dhabi-91 isolated from the Dammam region of Saudi Arabia. The obtained SNM was chemically characterized by various spectroscopic techniques such as UV, XRD, FTIR, SEM, TEM and EDAX; and its biological applications such as antimicrobial properties and antioxidant potential were recorded by DPPH methods. Biochemical and micromorphological studies together with the molecular techniques confirmed that the isolate Al-Dhabi-91 belonged to Streptomyces species. The characterization techniques confirmed that the UV spectrum showed maximum absorption peak at 305 nm indicating the plasmodium characteristics. SEM and TEM analyses evidenced 5-2 nm which are agglomerated, cool to form porous asymmetrical networks. Additionally, the FTIR spectrum showed maximum peak at 1194 cm(-1) and 1394 cm(-1), confirming the presence of aromatic C-H bending and aromatic C=C bending in the SNM. SNM exhibited prolific antibacterial activity against Gram negative pathogens, K. pneumoniae (28.33 mm) and E. coli (21.66 mm) respectively. The MIC values of SNM were significant with respect to E. faecalis (125 mu g/ml), S. aureus (250 mu g/ml), P. aeruginosa (125 mu g/ml), K. pneumoniae (500 g/ml) and E. coli (250 mu g/ml) respectively. In addition, the antioxidant potential of the SNM was another value added importance. Especially 50 mu g/m1 of the nanoparticles showed 33% antioxidant potential; similarly in nitric oxide radical inhibition assay the concentration of 50 mu g/ml nanoparticles showed 33% of inhibition potential. Overall, the eco-friendly synthesis of SNM from the marine StTeptomyces strain Al-Dhabi-91 was an ideal active source for the treatment of infectious disease and health associated disorders.