期刊
JOURNAL OF ORTHOPAEDIC RESEARCH
卷 38, 期 2, 页码 233-252出版社
WILEY
DOI: 10.1002/jor.24466
关键词
in vivo mechanical loading; bone adaptation; tibial loading
类别
资金
- NSF [CMMI 1463523]
- BBSRC [BB/I012702/1]
- NIH [R01-AR047867, R21AR071587]
- BBSRC [BB/I012702/1] Funding Source: UKRI
In vivo, tibial loading in mice is increasingly used to study bone adaptation and mechanotransduction. To achieve standardized and defined experimental conditions, loading parameters and animal-related factors must be considered when performing in vivo loading studies. In this review, we discuss these loading and animal-related experimental conditions, present methods to assess bone adaptation, and suggest reporting guidelines. This review originated from presentations by each of the authors at the workshop Developing Best Practices for Mouse Models of In Vivo Loading during the Preclinical Models Section at the Orthopaedic Research Society Annual Meeting, San Diego, CA, March 2017. Following the meeting, the authors engaged in detailed discussions with consideration of relevant literature. The guidelines and recommendations in this review are provided to help researchers perform in vivo loading experiments in mice, and thus further our knowledge of bone adaptation and the mechanisms involved in mechanotransduction.
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