期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 84, 期 19, 页码 12499-12507出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.9b02008
关键词
-
资金
- Slovak Grant Agency (VEGA) [1/0552/18, APVV-14-0147]
- Slovak Grant Agency (ITMS project) [26240120025]
A unified catalytic system for tandem Pd-catalyzed carbonylation and C-C cross-coupling via C-H activation was designed. The proposed cascade reaction allows a facile one-step construction of a tetracyclic isoindoloindole skeleton, in which three new C-C/C-N bonds are simultaneously formed. In detail, the carbonylation of aryl dibromides with indoles and C-H activation of in situ formed N-(2'-bromoaroyl)-indole provide biologically relevant 6H-isoindolo[2,1-a]indol-6-ones from commercially available substrates. The aminocarbonylation step in the proposed tandem reaction utilizes glyoxylic acid monohydrate as an environmentally friendly CO surrogate.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据