期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 84, 期 18, 页码 12221-12227出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.9b02020
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The concise and convergent total syntheses of (+)- and (-)-Fumimycin have been achieved by taking advantage of strategies for the asymmetric aza-Friedel-Crafts reaction of a highly substituted hydroquinone and N-fumaryl ketimine generated from the corresponding dehydroalanine. The enantiomerically pure natural product and its enantiomer were prepared in seven steps and 22% overall yield by employing both enantiomers of a BINOL-derived chiral phosphoric acid (CPA) catalyst.
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