期刊
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
卷 61, 期 11, 页码 887-897出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/JOM.0000000000001688
关键词
1; 3-butadiene; leukemia; multiple myeloma; non-hodgkin lymphoma; styrene; synthetic rubber worker mortality
资金
- International Institute of Synthetic Rubber Producers (IISRP)
- Olefins Panel of the American Chemistry Council
Objective: To evaluate 1943 to 2009 mortality among 22,785 synthetic rubber industry employees. Methods: Standardized mortality ratio (SMR) and internal Cox regression analyses. Results: Among hourly employees with more than or equal to 10 years worked and more than or equal to 20 years since hire, SMRs were elevated for leukemia (SMR = 139, 95% confidence interval [CI] = 106 to 179), non-Hodgkin lymphoma (NHL) (SMR = 136, CI = 102 to 177), bladder cancer (SMR = 148, CI = 110 to 195) and, for women only, lung cancer (SMR = 225, CI = 103 to 427). Butadiene and styrene exposure-response trends were positive for leukemia and bladder cancer but not for NHL or for lung cancer among women. Conclusions: Results support a causal relationship between butadiene and leukemia. Interpretation of results for lung cancer among women and for bladder cancer is uncertain because of inability to control for smoking and inadequate or inconsistent support from other studies for an association between butadiene or styrene and the latter cancers.
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