期刊
JOURNAL OF NEUROSCIENCE
卷 39, 期 45, 页码 8949-8968出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.2858-18.2019
关键词
electrophysiology; hippocampus; human; memory; neocortex; sleep
资金
- U.S. Office of Naval Research's Multidisciplinary University Research Initiatives Program [N00014 -16-1-2829]
- National Institute of Mental Health [RF1 MH117155, R01 MH111437]
- National Institute of Biomedical Imaging and Bioengineering [R01 EB009282]
Human anterior and posterior hippocampus (aHC, pHC) differ in connectivity and behavioral correlates. Here we report physiological differences in humans of both sexes. During NREM sleep, the human hippocampus generates sharpwave ripples (SWRs) similar to those which in rodents mark memory replay. Weshow that while pHC generates SWRs, it also generates approximately as many spindle ripples (SSR: ripples phase-locked to local spindles). In contrast, SSRs are rare in aHC. Like SWRs, SSRs often co-occur with neocortical theta bursts (TBs), downstates (DSs), sleep spindles (SSs), and upstates (USs), which coordinate cortico-hippocampal interactions and facilitate consolidation in rodents. SWRs co-occur with these waves in widespread cortical areas, especially frontocentral. These waves typically occur in the sequence TB-DS-SS-US, with SWRs usually occurring before SS-US. In contrast, SSRs occur similar to 350 ms later, with a strong preference for co-occurrence with posterior-parietal SSs. pHC-SSs were strongly phase-locked with parietal-SSs, and pHC-SSRs were phase-coupled with pHC-SSs and parietal-SSs. HumanSWRs (and associated replay events, if any) are separated by similar to 5 s on average, whereas ripples on successive SSR peaks are separated by only similar to 80 ms. These distinctive physiological properties of pHC-SSR enable an alternative mechanism for hippocampal engagement with neocortex.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据