期刊
JOURNAL OF NEUROSCIENCE
卷 39, 期 43, 页码 8584-8599出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1249-19.2019
关键词
BDNF/TrkB pathway; COX-2; neonatal ventral hippocampus lesion; oxidative/nitrosative stress; prefrontal cortex; risperidone
资金
- Spanish Ministry of Economy, Industry and Competitiveness (MINECO-EU-FEDER) [SAF2016-75500-R]
- PRODEP [CA-BUAP-120]
- CONACYT [252808]
- CONACYT
Reduction of the dendritic arbor length and the lack of dendritic spines in the pyramidal cells of the prefrontal cortex (PFC) are prevalent pathological features in schizophrenia (SZ). Neonatal ventral hippocampus lesion (NVHL) in male rats reproduces these neuronal characteristics and here we describe how this is a consequence of BDNF/TrkB pathway disruption. Moreover, COX-2 proinflammatory state, as well as Nrf-2 antioxidant impairment, triggers oxidative/nitrosative stress, which also contributes to dendritic spine impairments in the PFC. Interestingly, oxidative/nitrosative stress was also detected in the periphery of NVHL animals. Furthermore, risperidone treatment had a neurotrophic effect on the PFC and antioxidant effects on the brain and periphery of NVHL animals; these cellular effects were related to behavioral improvement. Our data highlight the link between brain development and immune response, as well as several other factors to understand mechanisms related to the pathophysiology of SZ.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据