期刊
JOURNAL OF NATURAL PRODUCTS
卷 82, 期 10, 页码 2673-2681出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.8b01056
关键词
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资金
- JSPS KAKENHI [15K07417, 16H05095]
- Grants-in-Aid for Scientific Research [16H05095, 15K07417] Funding Source: KAKEN
A new compound, designated nectriatide (1), was isolated as a potentiator of amphotericin B (AmB) activity against Candida albicans from the culture broth of Nectriaceae sp. BF-0114. This structure was elucidated based on spectroscopic analyses (1D and 2D NMR data), chemical methods, and total synthesis. Compound 1 was a unique cyclotetrapeptide consisting of L-N-methyltyrosine, anthranilic acid, L-alanine, and L-valine. Compound 1 and several synthetic derivatives, including linear peptides, potentiated AmB activity against C. albicans by up to 16-fold (the MIC value of AmB decreased from 0.5 mu g/mL to 0.031 mu g/mL in combination with test compound).
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