期刊
JOURNAL OF NATURAL PRODUCTS
卷 82, 期 9, 页码 2477-2482出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.9b00164
关键词
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资金
- National Natural Science Foundation of China [41830535, U1606403]
- National Key Research and Development Program of China [2018YFC0310900]
- Qingdao National Laboratory for Marine Science and Technology [2016ASKJ08]
- Fundamental Research Funds for the Central Universities of China [201762017]
- Taishan Scholars Program, China
- Scientific and Technological Innovation Project
Six new sordarin tetracyclic diterpene glycosides, moriniafungins B-G (1-6), and a new sordaricin tetracyclic diterpene, sordaricin B (8), together with two known analogues, moriniafungin (7) and sordaricin (9), were isolated from the zoanthid-derived fungus Curvularia hawaiiensis TA26-15. The structures of the new compounds were elucidated by comprehensive analyses of spectroscopic data, including ID and 2D NMR and MS data. Compounds 1-6 represent the first case of sordarins from marine-derived fungi possessing a sordarose with a spiro 1,3-dioxolan-4-one ring, which is rare in the nature. Compound 4 showed antifungal activity against Candida albicans ATCC10231 with an MIC value of 2.9 mu M.
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