期刊
JOURNAL OF NATURAL PRODUCTS
卷 82, 期 9, 页码 2544-2549出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.9b00403
关键词
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资金
- Bundesministerium fur Bildung and Forschung [03ZZ0808A]
- Deutsche Forschungsgemeinschaft [SFB1127 ChemBioSys]
- European Regional Development Fund [EFRE-0300098]
Precursor-directed biosynthesis was used to introduce selected aryl carboxylic acids into the pseudochelin pathway, which had recently been assembled in Myxococcus xanthus. Overall, 14 previously undescribed analogues of the natural products myxochelin B and pseudochelin A were generated and structurally characterized. A subset of 10 derivatives together with their parental molecules were evaluated for their activity toward human 5-lipoxygenase. This testing revealed pseudochelin A as the most potent 5-lipoxygenase inhibitor among the naturally occurring compounds, whereas myxochelin A is the least active. Replacement of the catechol moieties in myxochelin B and pseudochelin A affected the bioactivity to different degrees.
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