期刊
JOURNAL OF NATURAL PRODUCTS
卷 82, 期 8, 页码 2354-2358出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.9b00362
关键词
-
资金
- National Science Foundation [ANT-1043749, ANT-0838776, PLR-1341339]
- University of South Florida
The cold waters of Antarctica are known to harbor a rich biodiversity. Our continuing interest in the chemical analysis of Antarctic invertebrates has resulted in the isolation of friomaramide (1), a new, highly modified hexapeptide, from the Antarctic sponge Inflatella coelosphaeroides. The structure of friomaramide was determined using spectroscopic methods and its configuration established by Marfeys method. Friomaramide, which bears the unusual permethylation of the amino acid backbone and is the longest polypeptide bearing a tryptenamine C-terminus, blocks >90% of Plasmodium falciparum liver-stage parasite development at 6.1 mu M.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据