期刊
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
卷 133, 期 -, 页码 148-163出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.yjmcc.2019.06.010
关键词
DNA methylation; Histone modifications; microRNAs; Long non-coding RNAs; Cardiovascular diseases
资金
- Ministry of Health [GR2013_02355011]
- NIH [AG056848]
Cardiovascular disease remains the number one cause of death and disability worldwide despite significant improvements in diagnosis, prevention, and early intervention efforts. There is an urgent need for improved understanding of cardiovascular processes responsible for disease development in order to develop more effective therapeutic strategies. Recent knowledge gleaned from the study of epigenetic mechanisms in the vasculature has uncovered new potential targets for intervention. Herein, we provide an overview of epigenetic mechanism, and review recent findings related to epigenetics in vascular diseases, highlighting classical epigenetic mechanism such as DNA methylation and histone modification as well as the newly discovered non-coding RNA mechanisms.
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