期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 62, 期 19, 页码 8866-8872出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jmedchem.9b00936
关键词
-
资金
- NIH [DA038000, DA043507, DA033760]
- Swiss National Science Foundation [P2EZP3 175137]
- CSC [201606250107]
- Swiss National Science Foundation (SNF) [P2EZP3_175137] Funding Source: Swiss National Science Foundation (SNF)
Dysfunction of monoacylglycerol lipase (MAGL) is associated with several psychopathological disorders, including drug addiction and neurodegenerative diseases. Herein we design, synthesize, and evaluate several irreversible fluorine-containing MAGL inhibitors for positron emission tomography (PET) ligand development. Compound 6 (identified from a therapeutic agent) was advanced for F-18-labeling via a novel spirocyclic iodonium ylide (SCIDY) strategy, which demonstrated high brain permeability and excellent specific binding. This work supports further development of novel F-18-labeled MAGL PET probes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据