期刊
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
卷 36, 期 -, 页码 27-36出版社
JOURNAL MATER SCI TECHNOL
DOI: 10.1016/j.jmst.2019.04.038
关键词
Hydrothermal reactions; Ion-exchange; Dissolution-reprecipitation; Nanocrystals; Biphasic calcium phosphate; Bone substitute materials
资金
- National Key Research and Development Program of China from Ministry of Science andTechnology [2016YFC1100502]
- Key Research Program of Frontier Sciences from Chinese Academy of Sciences (CAS) [QYZDJ-SSW-JSC031]
- Key Research and Development Program of Liaoning Province [2017105005]
- Shenyang Key R&D and Technology Transfer Program [Z17-7-023]
Magnesium (Mg2+) ion plays important roles in biomineralization of bone, teeth and calcium carbonate skeletons. Herein, chicken eggshells mainly comprising of Mg-calcite nanocrystals (Mg/(Mg + Ca) (similar to)2.0 mol.%) were used to fabricate biphasic calcium phosphate (BCP), a mixture of hydroxyapatite (HA) and beta-tricalcium phosphate (beta-TCP) nanocrystals, through hydrothermal reactions at 200 degrees C for 24 h. Our results indicated that beta-TCP nanocrystals formed through the ion-exchange reactions of Mg-calcite, while HA nanocrystals were mainly produced by dissolution-reprecipitation reactions on the surfaces of eggshell samples in the hydrothermal system. Mg substitution in calcite resulted in formation of beta-TCP nanocrystals instead of HA crystals through ion-exchange reactions. BCP samples with different compositions ((similar to)28.6-77.8 wt.% beta-TCP) were produced by controlling particle sizes of eggshells for hydrothermal reactions. The larger particles lead to the larger proportion of beta-TCP in the BCP composition. Therefore, Mg substitution and particle size had synergetic effects on the hydrothermal synthesis of BCP using chicken eggshells through balance of ion-exchange and dissolution-reprecipitation reactions. Cell culture results showed that the BCP products were non-cytotoxic to MC3T3-E1 cells, which may be used for bone substitute materials in future. (C) 2019 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.
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