期刊
JOURNAL OF INFECTIOUS DISEASES
卷 220, 期 12, 页码 1962-1966出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiz410
关键词
controlled human malaria infection; cryopreservation; humans; Plasmodium falciparum
资金
- National Institutes of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Department of Health and Human Services [HSN272201300022I]
- NIH/NIAID [HHSN272201500002C]
- NIAID, NIH Phase II Small Business Innovation Research [2R44AI058375-06A1]
- NIAID [K23AI125720]
Direct venous inoculation of 3.2 x 10(3) aseptic, purified, cryopreserved, vialed Plasmodium falciparum (Pf) strain NF54 sporozoites, PfSPZ Challenge (NF54), has been used for controlled human malaria infection (CHMI) in the United States, 4 European countries, and 6 African countries. In nonimmune adults, this results in 100% infection rates. We conducted a double-blind, randomized, dose-escalation study to assess the infectivity of the 7G8 clone of Pf (PfSPZ Challenge [7G8]). Results showed dose-dependent infectivity from 43% for 8 x 10(2) PfSPZ to 100% for 4.8 x 10(3) PfSPZ. PfSPZ Challenge (7G8) will allow for more complete assessment by CHMI of antimalarial vaccines and drugs.
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