期刊
JOURNAL OF INFECTIOUS DISEASES
卷 221, 期 3, 页码 483-492出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiz473
关键词
Africa; antiretroviral therapy; children; gut microbiota; HIV infection
资金
- Global Health and Vaccination Programme of the Medical Research Council of Norway
- Northern Norway Regional Health Authority [1448-19]
- National Institutes of Health (NIH) Common Fund, through the Office of Strategic Coordination/Office of the NIH Director, National Institute of Environmental Health Sciences
- National Human Genome Institute of Health of the National Institutes of Health [U54HG009824, 1U01HG006961]
Background. Human immunodeficiency virus (HIV) infection causes impairment of the gastrointestinal barrier, with substantial depletion of CD4 (+) T cells in the gut. Antiretroviral therapy (ART) restores CD4 (+) counts and may have beneficial effects on gut microbiota in adults. Little is known about effect of long-term ART on gut microbiome in HIV-infected children. We investigated composition of gut microbiota in HIV-infected and -uninfected children and assessed associations between gut microbiota and patient characteristics. Methods. In a cross-sectional study, rectal swabs were collected from 177 HIV-infected and 103 HIV-uninfected controls. Gut microbial composition was explored using 16S ribosomal ribonucleic acid sequencing. Results. Human immunodeficiency virus-infected children had significantly lower alpha-diversity and higher beta-diversity compared to HIV-uninfected. No association was observed between microbiome diversity and CD4(+) T-cell count, HIV viral load, or HIV-associated chronic lung disease. We found enriched levels of Corynebacterium (P < .01), Finegoldia (P < .01), and Anaerococcus (P < .01) in HIV-infected participants and enrichment of Enterobacteriaceae (P = .02) in participants with low CD4(+) counts (<400 cells/mm(3)). Prolonged ART-treatment (10 years) was significantly associated with a richer gut microbiota by alpha diversity. Conclusions. Human immunodeficiency virus-infected children have altered gut microbiota. Prolonged ART may restore the richness of the microbiota closer to that of HIV-uninfected children.
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