Patients with dyspepsia have impaired mucosal integrity both in the duodenum and jejunum: in vivo assessment of small bowel mucosal integrity using baseline impedance

Background Recent studies reported that impaired proximal duodenal mucosa, assessed by duodenal biopsy, could play an important role in the development of dyspeptic symptoms. The aims of this study were (a) to develop a method to measure in vivo duodenal and jejunal baseline impedance (BI) and (b) to assess small bowel mucosal integrity in patients with functional dyspepsia (FD) and healthy controls (HC). Methods We recruited 16 patients with FD and 15 HC. All subjects underwent ambulatory duodeno-jejunal manometry combined with impedance (HRM/Z), BI were determined by measuring impedance immediately after the passage of nocturnal migrating motor complex (MMC) phase IIIs. Results The number of MMC phase IIIs in FD was significantly lower than that in HC (2.6 +/- 1.4 vs 4.8 +/- 1.7, p < 0.001). The BI in patients was significantly lower than that in HC in D1(164.2 +/- 59.8 ohm in FD and 243.1 +/- 40.5 ohm in HC, p = 0.0061), D2 (191.2 +/- 34.1 and 256.5 +/- 91.4 ohm, p = 0.01), D3 (214.0 +/- 76.9 and 278.1 +/- 45.3 ohm, p = 0.009), D4 (270.8 +/- 54.2 and 351.8 +/- 50.2 ohm, p < 0.001), and J1 (312.2 +/- 55.4 and 379.3 +/- 38.3 ohm, p = 0.001). Conclusions This is the first study reporting the duodenal and jejunal BI in vivo. The results have shown significantly lowered BI in the proximal small intestine in patients with FD compared to HC. Furthermore it suggests that measurements of small bowel BI could be used as a biomarker for diagnosis and follow up of patients with FD.