期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 216, 期 11, 页码 2466-2478出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20190993
关键词
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资金
- National Institutes of Health/National Cancer Institute Cancer Center Support Grant [P30 CA008748]
- National Institutes of Health [R37 AI034206]
- Ludwig Center at the Memorial Sloan Kettering Cancer Center
Regulatory T (T reg) cells, a specialized subset of CD4(+) T cells, are essential to prevent fatal autoimmunity. Expression of the T reg lineage-defining transcription factor Foxp3, and therefore their differentiation in the thymus, is dependent upon T cell receptor (TCR) and interleukin-2 (IL-2) signaling. Here, we report that the majority of IL-2-producing cells in the thymus are mature CD4 single-positive (CD4SP) thymocytes and that continuous IL-2 production sustained thymic T reg cell generation and control of systemic immune activation. Furthermore, single-cell RNA sequencing analysis of CD4 thymocyte subsets revealed that IL-2 was expressed in self-reactive CD4SP thymocytes, which also contain T reg precursor cells. Thus, our results suggest that the thymic T reg cell pool size is scaled by a key niche factor, IL-2, produced by self-reactive CD4SP thymocytes. This IL-2-dependent scaling of thymic T reg cell generation by overall self-reactivity of a mature post-selection thymic precursor pool may likely ensure adequate control of autoimmunity.
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