期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 25, 期 23, 页码 5632-5635出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2015.10.025
关键词
Nucleic acid-based therapeutics; Prodrug; Protecting group; Hypoxia; Hybridization
资金
- Strategic Research Base Development Program for Private Universities (Kanagawa University) from the Ministry of Education, Culture, Sports, Science, and Technology, Japan
- Takahashi Industrial and Economic Research Foundation
Oligonucleotides containing 4-O-(4-NO2-benzyl)thymine residues were synthesized to assess potential prodrug-type action against hypoxic cells. These modified oligonucleotides were incapable of stable duplex formation under non-hypoxic conditions. However, following deprotection of the thymine residues under bioreductive conditions, the deprotected oligonucleotides were able to form stable duplexes with target oligonucleotides. (C) 2015 Elsevier Ltd. All rights reserved.
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