期刊
JOURNAL OF CONTROLLED RELEASE
卷 309, 期 -, 页码 106-124出版社
ELSEVIER
DOI: 10.1016/j.jconrel.2019.07.020
关键词
Cell penetrating peptides; Membrane transduction; Disorders; Therapeutic agents
资金
- Major Research Project of Shandong Province, P.R.China [2018GSF118004]
- Shandong Provincial Major Science &Technology Innovation Project, P.R.China [2018CXGC1411]
- Major Basic Research Projects of Shandong Natural Science Foundation, P.R.China [ZR2018ZC0232]
The selective infiltration of cell membranes and tissue barriers often blocks the entry of most active molecules. This natural defense mechanism prevents the invasion of exogenous substances and limits the therapeutic value of most available molecules. Therefore, it is particularly important to find appropriate ways of membrane translocation and therapeutic agent delivery to its target site. Cell penetrating peptides (CPPs) are a group of short peptides harnessed in this condition, possessing a significant capacity for membrane transduction and could be exploited to transfer various biologically active cargoes into the cells. Since their discovery, CPPs have been employed for delivery of a wide variety of therapeutic molecules to treat various disorders including cranial nerve involvement, ocular inflammation, myocardial ischemia, dermatosis and cancer. The promising results of CPPs-derived therapeutics in various tumor models demonstrated a potential and worthwhile scope of CPPs in chemotherapy. This review describes the detailed description of CPPs and CPPs-assisted molecular delivery against various tissues and organs disorders. An emphasis is focused on summarizing the novel insights and achievements of CPPs in surmounting the natural membrane barriers during the last 5 years.
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