期刊
JOURNAL OF COLLOID AND INTERFACE SCIENCE
卷 551, 期 -, 页码 39-46出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2019.04.096
关键词
Cyclodextrin based metal-organic; framework; Cubic gel particle; Cross linking; Glutathione sensitive; Intracellular drug release
资金
- National Natural Science Foundation of China [81603034, 81872813]
- China Postdoctoral Science Foundation [2016M591966]
- State Project for Essential Drug Research and Development [2017ZX09301075]
- 111 project [B16046]
- Funding of Double First-Rate Discipline Construction [CPU2018GY13]
- Program for Jiangsu Province Innovative Research Team
Novel cubic gel particles (ssCGP) with Glutathione (GSH) triggered drug release features were prepared by crosslinking the cyclodextrin based metal-organic frameworks (CD-MOFs) templets with a newly synthesized biodegradable disulfide bond-bearing linker and removing of the potassium ion in sequence. The morphology and size of ssCGP were investigated by field emission scanning electron microscope (FESEM) and dynamic light scattering. Energy dispersive x-ray spectroscopy (EDX), fourier transform infrared spectroscopy (FT-IR), powder x-ray diffraction (PXRD) and Brunauer-Emmett-Teller (BET) were employed to characterize the structure of ssCGP. ssCGP have regular hexahedron shape with edge length about 200-400 nm. Excellent ability of drug adsorption was achieved by using doxorubicin (DOX) as a model drug. The GSH triggered drug release of ssCGP was observed both in GSH contained solutions and intracellular environments. ssCGP have been demonstrated as a biocompatible porous nanocarrier, particular for intracellular drug delivery. (C) 2019 Elsevier Inc. All rights reserved.
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