期刊
JOURNAL OF CLINICAL PERIODONTOLOGY
卷 46, 期 12, 页码 1166-1182出版社
WILEY
DOI: 10.1111/jcpe.13188
关键词
diagnostic accuracy; gingival crevicular fluid; meta-analysis; molecular biomarkers; periodontitis; predictive values; prevalence; sensitivity; specificity; systematic review
资金
- FEDER (A way of making Europe) [ISCIII/PI17/01722]
- Conselleria de Cultura, Educacion e Ordenacion Universitaria da Xunta de Galicia (Spain) [ED431B 2017/029]
- Instituto de Salud Carlos III (General Division of Evaluation and Research Promotion, Madrid, Spain)
- [ED481A-2017]
Aim To analyse, by means of a meta-analytical approach, the diagnostic accuracy of molecular biomarkers in gingival crevicular fluid (GCF) for the detection of periodontitis in systemically healthy subjects. Material and Methods Studies on GCF molecular biomarkers providing a binary classification table (or sensitivity and specificity values and group sample sizes) in individuals with clinically diagnosed periodontitis were considered eligible. The search was performed using six electronic databases. The methodological quality of studies was assessed through the tool Quality Assessment of Diagnostic Studies. Meta-analyses were performed using the Hierarchical Summary Receiver Operating Characteristic, which adjusts classification data using random effects logistic regression. Results The included papers identified 36 potential biomarkers for the detection of periodontitis and for four of them meta-analyses were performed. The median sensitivity and specificity were for MMP8, 76.7% and 92.0%; for elastase, 74.6% and 81.1%; for cathepsin, 72.8% and 67.3%, respectively. The worst estimates of sensitivity and specificity were for trypsin (71.3% and 66.1%, respectively). Conclusions MMP8 showed good sensitivity and excellent specificity, which resulted in this biomarker being clinically the most useful or effective for the diagnosis of periodontitis in systemically healthy subjects, regardless of smoking condition.
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