期刊
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
卷 104, 期 12, 页码 6291-6300出版社
ENDOCRINE SOC
DOI: 10.1210/jc.2019-00743
关键词
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资金
- National Institute on Aging at the National Institutes of Health [U01AG029824]
- National Cancer Institute at the National Institutes of Health [U01AG029824]
- National Health and Medical Research Council (NHMRC) of Australia [34047, 1127060]
- Monash University (Australia)
- Victorian Cancer Agency (Australia)
- Commonwealth Scientific and Industrial Research Organisation (Flagship Grant)
- National Cancer Institute [U01AG029824]
- Monash University
- NHMRC of Australia [1105305]
- NHMRC [1135843]
- National Health and Medical Research Council of Australia [1105305] Funding Source: NHMRC
Context: There is a lack of understanding of what is normal in terms of sex steroid levels in older women. Objective: To determine whether sex steroid levels vary with age in and establish reference ranges for women >70 years of age. Design and Setting: Cross-sectional, community-based study. Participants: Included 6392 women >= 70 years of age. Main Outcome Measures: Sex steroids measured by liquid chromatography-tandem mass spectrometry. A reference group, to establish sex steroid age-specific reference ranges, excluded women using systemic or topical sex steroid, antiandrogen or glucocorticoid therapy, or an antiglycemic agent. Results: The reference group of 5326 women had a mean age of 75.1 (+/- 4.2) years, range of 70 to 94.7 years. Median values (range) were 181.2 pmol/L (3.7 to 5768.9) for estrone (E-1), 0.38 nmol/L (0.035 to 8.56) for testosterone (T), 2.60 nmol/L (0.07 to 46.85) for dehydroepiandrosterone (DHEA), and 41.6 nmol/L (2.4 to 176.6) for SHBG. Estradiol and DHT were below method sensitivity in 66.1% and 72.7% of the samples, respectively. Compared with women aged 70 to 74 years, women aged >= 85 years had higher median levels of E-1 (11.7%, P = 0.01), T (11.3%, P = 0.02), and SHBG (22.7%, P < 0.001) and lower DHEA (30% less, P < 0.001). Women with overweight and obesity had higher E-1 (P < 0.001) and T (P < 0.03) and lower SHBG (P < 0.001) than did women with normal body mass index. Smokers had 17.2% higher median T levels (P = 0.005). Conclusion: From the age of 70 years, T and E-1 increase with age, despite a steady decline in DHEA. Whether E-1 and T are biomarkers for longevity or contribute to healthy aging merits investigation.
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