期刊
JOURNAL OF CHROMATOGRAPHY A
卷 1609, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.chroma.2019.460512
关键词
Preservatives; Food control; (NZ)-N-(1-nitroethylidene)hydroxylamine; Single-laboratory Validation approach; Random uncertainty; Systematic uncertainties
资金
- FAPESC -Fundacao de Amparo a Pesquisa e Inovacao do Estado de Santa Catarina [635/2017]
The simultaneous use of nitrite and sorbate as preservatives in meat products may produce mutagenic compounds such as the ethylnitrolic acid and 2-methyl-1,4-dinitro-pyrrole. We developed a sensitive analytical method with high metrological reliability. After assessing several extraction approaches and chromatographic separation modes, a modified Quick, Easy, Cheap, Effective, Rugged and Safe (QuEChERS) approach was chosen for sample preparation, which were analyzed by reversed-phase liquid chromatography (with C-18 as stationary phase) coupled to tandem mass spectrometry. After validation, we confirmed that this method is fit-for-purpose, since it was applied to the analysis of several meat products. Limits of detection were set from 5 to 20 mu g kg(-1). Satisfactory results were obtained for both compounds, such as precision (CV > 20%) and recoveries (77-92%). This method determine these carcinogenic compounds in processed meats, contributing to the preservation of public health and the improvement of food regulation and control. (C) 2019 Elsevier B.V. All rights reserved.
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