期刊
JOURNAL OF CELLULAR BIOCHEMISTRY
卷 121, 期 1, 页码 661-671出版社
WILEY
DOI: 10.1002/jcb.29313
关键词
competing endogenous RNA; globlastoma multiforme; HAS2-AS1; tumorigenesis
资金
- National Key R&D Program of China [2017YFC1308401]
- National Natural Science Foundation of China [81671144, 91746205]
- Tianjin Natural Science Foundation [17JCZDJC36100]
Glioblastoma multiforme (GBM) is a refractory tumor with poor prognosis and requires more effective treatment regimens. It has been confirmed that long noncoding RNAs (lncRNAs) substantially regulate various human disease including GBM. However, the biological roles and its underlying molecular mechanisms still need to be further investigated. In this study, the biological function and potential molecular mechanism of lncHAS2-AS1 in GBM were explored. It was discovered that HAS2-AS1 was elevated in glioma tissues and correlated with the prognosis of patients with glioma. Reduction of HAS2-AS1 suppressed the migration and invasion in vitro and in vivo. The transcription factor STAT1 could raise HAS2-AS1 by binding to its promoter region. Besides, HAS2-AS1 could adjust PRPS1 via sponging miR-608 in a direct manner. On the whole, the results of this study evidence that HAS2-AS1 is an oncogene and a potential therapeutic target for GBM.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据