期刊
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
卷 24, 期 5, 页码 2704-2716出版社
WILEY
DOI: 10.1111/jcmm.14630
关键词
cardiac cell therapy; cardiac microenvironment; cardiac regeneration; cell-biomaterial interaction; immunomodulation; tissue engineering
资金
- Tor VergataUniversity, Grant Mission: Sustainability (D.R. 2817/2016) [E86C18000640005]
- Regione Lazio, Progetto SMARTIES (Smart scaffold ingegnerizzati per la rigenerazione dell'apparato muscolo scheletrico) PROGETTI DI GRUPPI DI RICERCA [85-2017-15004]
Regenerative therapies including stem cell treatments hold promise to allow curing patients affected by severe cardiac muscle diseases. However, the clinical efficacy of stem cell therapy remains elusive, so far. The two key roadblocks that still need to be overcome are the poor cell engraftment into the injured myocardium and the limited knowledge of the ideal mixture of bioactive factors to be locally delivered for restoring heart function. Thus, therapeutic strategies for cardiac repair are directed to increase the retention and functional integration of transplanted cells in the damaged myocardium or to enhance the endogenous repair mechanisms through cell-free therapies. In this context, biomaterial-based technologies and tissue engineering approaches have the potential to dramatically impact cardiac translational medicine. This review intends to offer some consideration on the cell-based and cell-free cardiac therapies, their limitations and the possible future developments.
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