4.5 Article

Targeted fluorescent probes for detection of oxidative stress in the mitochondria

期刊

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 25, 期 17, 页码 3476-3480

出版社

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2015.07.011

关键词

Mitochondria-targeting; Oxidative stress; Fluorescence probes

资金

  1. NIH [GM088795-01]
  2. NSF [1048655]
  3. NASA [MSGC R85197]
  4. MIIE [1204010]
  5. VPR-SI fund [R01386]
  6. Research Excellence Fund [R01121, R01323]

向作者/读者索取更多资源

Mitochondrial oxidative stress has been implicated in aging, neurodegenerative diseases, diabetes, stroke, ischemia/reperfusion injury, age-related macular degeneration (AMD) and cancer. Recently, we developed two new mitochondria-targeting fluorescent probes, MitoProbes I/II, which specifically localize in mitochondria and employed both in vivo and in vitro for detection of mitochondrial oxidative stress. Here, we report the design and synthesis of these agents, as well as their utility for real-time imaging of mitochondrial oxidative stress in cells. Published by Elsevier Ltd.

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