期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 25, 期 16, 页码 3199-3202出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2015.05.088
关键词
Antifungal; Lipopeptide; Burkholdine; Structure activity relationship study
资金
- Yamagata University Research Fund
- Grants-in-Aid for Scientific Research [25450145] Funding Source: KAKEN
Cyclic and linear lipopeptides, burkholdine analogues, were synthesized by conventional Fmoc-SPPS and cyclisation with DIPC/HOBt in the solution phase. Synthesized peptides were evaluated for antifungal activities with MIC values against Saccharomyces cerevisiae and Aspergillus oryzae. As a result, the stereochemistry of the amino acid residues and sequences of burkholdine analogues exerted a significant influence on antifungal activities. In addition, we found a linear burkholdine analogue with moderate antifungal activities. (C) 2015 Elsevier Ltd. All rights reserved.
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