期刊
ATHEROSCLEROSIS
卷 248, 期 -, 页码 51-61出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2016.02.025
关键词
Atherosclerosis; Long noncoding RNAs; Lipid; Vascular function; Vascular inflammation
资金
- Natural Science Foundation of Hubei Province, China [2014CFC1035]
- National Natural Science Foundation of China [81400794]
Atherosclerosis is universally recognized as a chronic lipid-induced inflammation of the vessel wall in response to dyslipidemia and haemodynamic stress involving dysfunction and activation of resident vascular cells as well as infiltration of leukocytes. As members of nonprotein-coding RNAs, the long noncoding RNAs (lncRNAs) are implicated in various biological processes. Accumulating evidences suggest that lncRNAs regulate the function of vascular wall, activation of macrophages, lipid metabolism and immune response. Here, we review the effects of lncRNAs on the progress of atherosclerosis. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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