Synthesis of a novel series of fluoroarene derivatives of artemisinin as potent antifungal and anticancer agent

A series of new fluoroarene derivatives of artemisinin were prepared using Suzuki and Sonogashira cross-coupling reactions. An antifungal and antitumor activity was evaluated against opportunistic pathogen Fusarium oxysporum and Hela cancer cell line. All these derivatives have shown moderate to good activity. (C) 2015 Elsevier Ltd. All rights reserved.