期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 20, 期 18, 页码 -出版社
MDPI
DOI: 10.3390/ijms20184611
关键词
aneuploidy; metabolism; oxidative stress; reactive oxygen species; glycolysis; DNA damage
Alterations from the normal set of chromosomes are extremely common as cells progress toward tumourigenesis. Similarly, we expect to see disruption of normal cellular metabolism, particularly in the use of glucose. In this review, we discuss the connections between these two processes: how chromosomal aberrations lead to metabolic disruption, and vice versa. Both processes typically result in the production of elevated levels of reactive oxygen species, so we particularly focus on their role in mediating oncogenic changes.
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