相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。In-vivo genetic ablation of metabotropic glutamate receptor type 5 slows down disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis
Tiziana Bonifacino et al.
NEUROBIOLOGY OF DISEASE (2019)
Constitutive downregulation protein kinase C epsilon in hSOD1G93A astrocytes influences mGluR5 signaling and the regulation of glutamate uptake
Maxime Vergouts et al.
GLIA (2018)
Functional organization of postsynaptic glutamate receptors
Nicky Scheefhals et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2018)
Genetic inactivation of mGlu5 receptor improves motor coordination in the Grm1(crv4) mouse model of SCAR13 ataxia
Simone Bossi et al.
NEUROBIOLOGY OF DISEASE (2018)
Autophagy is increased following either pharmacological or genetic silencing of mGluR5 signaling in Alzheimer's disease mouse models
Khaled S. Abd-Elrahman et al.
MOLECULAR BRAIN (2018)
Safety and efficacy of edaravone in well defined patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial
Koji Abe et al.
LANCET NEUROLOGY (2017)
In-vivo effects of knocking-down metabotropic glutamate receptor 5 in the SOD1G93A mouse model of amyotrophic lateral sclerosis
Tiziana Bonifacino et al.
NEUROPHARMACOLOGY (2017)
Amyotrophic lateral sclerosis
Orla Hardiman et al.
NATURE REVIEWS DISEASE PRIMERS (2017)
Motor neuron vulnerability and resistance in amyotrophic lateral sclerosis
Jik Nijssen et al.
ACTA NEUROPATHOLOGICA (2017)
Blocking metabotropic glutamate receptor subtype 5 relieves maladaptive chronic stress consequences
Daniel Peterlik et al.
BRAIN BEHAVIOR AND IMMUNITY (2017)
Current Therapy of Drugs in Amyotrophic Lateral Sclerosis
Haiyan Lu et al.
CURRENT NEUROPHARMACOLOGY (2016)
Altered mechanisms underlying the abnormal glutamate release in amyotrophic lateral sclerosis at a pre-symptomatic stage of the disease
Tiziana Bonifacino et al.
NEUROBIOLOGY OF DISEASE (2016)
ASTROCYTIC mGluR5 AND THE TRIPARTITE SYNAPSE
A. Panatier et al.
NEUROSCIENCE (2016)
Oligodendrocytes contribute to motor neuron death in ALS via SOD1-dependent mechanism
Laura Ferraiuolo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Exocytosis regulates trafficking of GABA and glycine heterotransporters in spinal cord glutamatergic synapses: a mechanism for the excessive heterotransporter-induced release of glutamate in experimental amyotrophic lateral sclerosis
Marco Milanese et al.
NEUROBIOLOGY OF DISEASE (2015)
Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways
Elizabeth T. Cirulli et al.
SCIENCE (2015)
Pharmacology of Basimglurant (RO4917523, RG7090), a Unique Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator in Clinical Development for Depression
Lothar Lindemann et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2015)
Role of calpain-1 in the early phase of experimental ALS
R. Stifanese et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2014)
Chronic Metabotropic Glutamate Receptor 5 Inhibition Corrects Local Alterations of Brain Activity and Improves Cognitive Performance in Fragile X Mice
Aubin Michalon et al.
BIOLOGICAL PSYCHIATRY (2014)
The Glutamate Hypothesis in ALS: Pathophysiology and Drug Development
H. Blasco et al.
CURRENT MEDICINAL CHEMISTRY (2014)
Genetic counselling in ALS: facts, uncertainties and clinical suggestions
Adriano Chio et al.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2014)
Proteomic Analysis of Gliosomes from Mouse Brain: Identification and Investigation of Glial Membrane Proteins
Karen E. Carney et al.
JOURNAL OF PROTEOME RESEARCH (2014)
State of play in amyotrophic lateral sclerosis genetics
Alan E. Renton et al.
NATURE NEUROSCIENCE (2014)
The phenotypic variability of amyotrophic lateral sclerosis
Bart Swinnen et al.
NATURE REVIEWS NEUROLOGY (2014)
Knocking down metabotropic glutamate receptor 1 improves survival and disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis☆
Marco Milanese et al.
NEUROBIOLOGY OF DISEASE (2014)
Microglia Induce Motor Neuron Death via the Classical NF-κB Pathway in Amyotrophic Lateral Sclerosis
Ashley E. Frakes et al.
NEURON (2014)
The role of oligodendroglial dysfunction in amyotrophic lateral sclerosis
Annelies Nonneman et al.
NEURODEGENERATIVE DISEASE MANAGEMENT (2014)
Cognitive changes predict functional decline in ALS A population-based longitudinal study
Marwa Elamin et al.
NEUROLOGY (2013)
Group I metabotropic glutamate autoreceptors induce abnormal glutamate exocytosis in a mouse model of amyotrophic lateral sclerosis
Francesco Giribaldi et al.
NEUROPHARMACOLOGY (2013)
CCL5-glutamate interaction in central nervous system: Early and acute presynaptic defects in EAE mice
Silvia Di Prisco et al.
NEUROPHARMACOLOGY (2013)
The BH4 domain of Bcl-XL rescues astrocyte degeneration in amyotrophic lateral sclerosis by modulating intracellular calcium signals
Francesca Martorana et al.
HUMAN MOLECULAR GENETICS (2012)
A new approach to analyze cell surface protein complexes reveals specific heterodimeric metabotropic glutamate receptors
Etienne Doumazane et al.
FASEB JOURNAL (2011)
Motor Neuron Impairment Mediated by a Sumoylated Fragment of the Glial Glutamate Transporter EAAT2
Emily Foran et al.
GLIA (2011)
Abnormal exocytotic release of glutamate in a mouse model of amyotrophic lateral sclerosis
Marco Milanese et al.
JOURNAL OF NEUROCHEMISTRY (2011)
Astrocytes from familial and sporadic ALS patients are toxic to motor neurons
Amanda M. Haidet-Phillips et al.
NATURE BIOTECHNOLOGY (2011)
Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis
Laura Ferraiuolo et al.
NATURE REVIEWS NEUROLOGY (2011)
A prolonged pharmacological blockade of type-5 metabotropic glutamate receptors protects cultured spinal cord motor neurons against excitotoxic death
Simona D'Antoni et al.
NEUROBIOLOGY OF DISEASE (2011)
AFQ056, a new mGluR5 antagonist for treatment of fragile X syndrome
Josien Levenga et al.
NEUROBIOLOGY OF DISEASE (2011)
Metabotropic glutamate receptors: From the workbench to the bedside
E. Nicoletti et al.
NEUROPHARMACOLOGY (2011)
Disease-Related Changes in the Cerebrospinal Fluid Metabolome in Amyotrophic Lateral Sclerosis Detected by GC/TOFMS
Anna Wuolikainen et al.
PLOS ONE (2011)
CTEP: A Novel, Potent, Long-Acting, and Orally Bioavailable Metabotropic Glutamate Receptor 5 Inhibitor
Lothar Lindemann et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2011)
Adaptive Modifications in the Calpain/Calpastatin System in Brain Cells after Persistent Alteration in Ca2+ Homeostasis
Roberto Stifanese et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
In vitro activation of GAT1 transporters expressed in spinal cord gliosomes stimulates glutamate release that is abnormally elevated in the SOD1/G93A(+) mouse model of amyotrophic lateral sclerosis
Marco Milanese et al.
JOURNAL OF NEUROCHEMISTRY (2010)
A new subtype of frontotemporal lobar degeneration with FUS pathology
Manuela Neumann et al.
BRAIN (2009)
Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond
Hristelina Ilieva et al.
JOURNAL OF CELL BIOLOGY (2009)
A pilot open label, single dose trial of fenobam in adults with fragile X syndrome
E. Berry-Kravis et al.
JOURNAL OF MEDICAL GENETICS (2009)
The Metabotropic Glutamate Receptor Subtype 5 Antagonist Fenobam Is Analgesic and Has Improved in Vivo Selectivity Compared with the Prototypical Antagonist 2-Methyl-6-(phenylethynyl)-pyridine
Michael C. Montana et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2009)
Focal degeneration of astrocytes in amyotrophic lateral sclerosis
D. Rossi et al.
CELL DEATH AND DIFFERENTIATION (2008)
Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis
Koji Yamanaka et al.
NATURE NEUROSCIENCE (2008)
Metabotropic Glutamate Receptors in Glial Cells
Simona D'Antoni et al.
NEUROCHEMICAL RESEARCH (2008)
Functional expression of release-regulating glycine transporters GLYT1 on GABAergic neurons and GLYT2 on astrocytes in mouse spinal cord
Luca Raiteri et al.
NEUROCHEMISTRY INTERNATIONAL (2008)
Presynaptic mGlu1 and mGlu5 autoreceptors facilitate glutamate exocytosis from mouse cortical nerve endings
Veronica Musante et al.
NEUROPHARMACOLOGY (2008)
Mechanisms of glutamate release elicited in rat cerebrocortical nerve endings by 'pathologically' elevated extraterminal K+ concentrations
Luca Raiteri et al.
JOURNAL OF NEUROCHEMISTRY (2007)
Emerging functions of the calpain superfamily of cysteine proteases in neuroendocrine secretory pathways
Joanne S. Evans et al.
JOURNAL OF NEUROCHEMISTRY (2007)
Onset and progression in inherited ALS determined by motor neurons and microglia
Severine Boillee et al.
SCIENCE (2006)
Protective effect of metabotropic glutamate receptor inhibition on amyotrophic lateral sclerosis-cerebrospinal fluid toxicity in vitro
J. M. H. Anneser et al.
NEUROSCIENCE (2006)
Fenobam:: A clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity
RHP Porter et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)
Altered expression of the glutamate transporter EAAT2b in neurological disease
NJ Maragakis et al.
ANNALS OF NEUROLOGY (2004)
Differential expression of mGluR5 in human lumbosacral motoneurons
JMH Anneser et al.
NEUROREPORT (2004)
Glial proliferation and metabotropic glutamate receptor expression in amyotrophic lateral sclerosis
JMH Anneser et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2004)
Excessive and precocious glutamate release in a mouse model of amyotrophic lateral sclerosis
L Raiteri et al.
NEUROPHARMACOLOGY (2004)
Activation of a glycine transporter on spinal cord neurons causes enhanced glutamate release in a mouse model of amyotrophic lateral sclerosis
L Raiteri et al.
BRITISH JOURNAL OF PHARMACOLOGY (2003)
Functional metabotropic glutamate receptors are expressed in oligodendrocyte progenitor cells
K Luyt et al.
JOURNAL OF NEUROCHEMISTRY (2003)
Glutamate levels in cerebrospinal fluid in amyotrophic lateral sclerosis: a reappraisal using a new HPLC method with coulometric detection in a large cohort of patients
O Spreux-Varoquaux et al.
JOURNAL OF THE NEUROLOGICAL SCIENCES (2002)
The Metabotropic Glutamate Receptors: Structure, Activation Mechanism and Pharmacology
Jean-Philippe Pin et al.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2002)
Synaptosomal and vesicular accumulation of L-glutamate, L-aspartate and D-aspartate
MW Fleck et al.
NEUROCHEMISTRY INTERNATIONAL (2001)
Immunohistochemical localization of group I and II metabotropic glutamate receptors in control and amyotrophic lateral sclerosis human spinal cord: Upregulation in reactive astrocytes
E Aronica et al.
NEUROSCIENCE (2001)
Neuroprotection by metabotropic glutamate receptor agonists on kainate-induced degeneration of motor neurons in spinal cord slices from adult rat
M Pizzi et al.
NEUROPHARMACOLOGY (2000)
分享论文
