期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 25, 期 15, 页码 3024-3029出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2015.05.004
关键词
15-Lipoxygenase; Inhibitors; Arachidonic acid; Pyrazole; Triazole; Benzoxazole
资金
- Biolipox AB
Investigation of 1N-substituted pyrazole-3-carboxanilides as 15-lipoxygenase-1 (15-LOX-1) inhibitors demonstrated that the 1N-substituent was not essential for activity or selectivity. Additional halogen substituents on the pyrazole ring, however, increased activity. Further development led to triazole-4-carboxanilides and 2-(3-pyrazolyl) benzoxazoles, which are potent and selective 15-LOX-1 inhibitors. (C) 2015 Elsevier Ltd. All rights reserved.
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