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Jin Soo Kim et al.
NATURAL PRODUCT RESEARCH (2018)
Cafestol, a coffee diterpene, inhibits urotensin II-induced interleukin-8 expression in human umbilical vein endothelial cells
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EUROPEAN JOURNAL OF PHARMACOLOGY (2018)
Cafestol Inhibits Cyclic-Strain-Induced Interleukin-8, Intercellular Adhesion Molecule-1, and Monocyte Chemoattractant Protein-1 Production in Vascular Endothelial Cells
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OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)
Nuclear FAK and its kinase activity regulate VEGFR2 transcription in angiogenesis of adult mice
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SCIENTIFIC REPORTS (2018)
Kahweol inhibits proliferation and induces apoptosis by suppressing fatty acid synthase in HER2-overexpressing cancer cells
Suck Hoon Oh et al.
FOOD AND CHEMICAL TOXICOLOGY (2018)
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CONNECTIVE TISSUE RESEARCH (2018)
Coffee and the risk of hepatocellular carcinoma and chronic liver disease: a systematic review and meta-analysis of prospective studies
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EUROPEAN JOURNAL OF CANCER PREVENTION (2017)
Cafestol, a Bioactive Substance in Coffee, Has Antidiabetic Properties in KKAy Mice
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JOURNAL OF NATURAL PRODUCTS (2017)
The coffee diterpene kahweol enhances sensitivity to sorafenib in human renal carcinoma Caki cells through down-regulation of Mcl-1 and c-FLIP expression
Kyoung-Jin Min et al.
ONCOTARGET (2017)
Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes
Robin Poole et al.
BMJ-BRITISH MEDICAL JOURNAL (2017)
Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes
Robin Poole et al.
BMJ-BRITISH MEDICAL JOURNAL (2017)
Kahweol inhibits lipid accumulation and induces Glucose-uptake through activation of AMP-activated protein kinase (AMPK)
Jung-Hwan Baek et al.
BMB REPORTS (2017)
Cafestol, a diterpene molecule found in coffee, induces leukemia cell death
Caue S. Limaa et al.
BIOMEDICINE & PHARMACOTHERAPY (2017)
Kahweol from Coffee Induces Apoptosis by Upregulating Activating Transcription Factor 3in Human Colorectal Cancer Cells
Gwang Hun Park et al.
BIOMOLECULES & THERAPEUTICS (2017)
Mechanisms and consequences of Jak-STAT signaling in the immune system
Alejandro V. Villarino et al.
NATURE IMMUNOLOGY (2017)
Coffee consumption and risk of the metabolic syndrome: A meta-analysis
F. Shang et al.
DIABETES & METABOLISM (2016)
The clinicopathological significance of angiogenesis in hindgut neuroendocrine tumors obtained via an endoscopic procedure
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DIAGNOSTIC PATHOLOGY (2016)
The coffee diterpene kahweol suppresses the cell proliferation by inducing cyclin D1 proteasomal degradation via ERK1/2, JNK and GKS3β-dependent threonine-286 phosphorylation in human colorectal cancer cells
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FOOD AND CHEMICAL TOXICOLOGY (2016)
Kahweol induces apoptosis by suppressing BTF3 expression through the ERK signaling pathway in non-small cell lung cancer cells
Young-Joo Jeon et al.
INTERNATIONAL JOURNAL OF ONCOLOGY (2016)
Anti-Angiogenic Properties of Cafestol and Kahweol Palmitate Diterpene Esters
Marzieh Moeenfard et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2016)
Coffee and cancer risk: A meta-analysis of prospective observational studies
Anqiang Wang et al.
SCIENTIFIC REPORTS (2016)
Cafestol has a weaker inhibitory effect on osteoclastogenesis than kahweol and promotes osteoblast differentiation
Yutaka Fukuma et al.
BIOFACTORS (2015)
The Cytotoxicity of Kahweol in HT-29 Human Colorectal Cancer Cells Is Mediated by Apoptosis and Suppression of Heat Shock Protein 70 Expression
Dong Wook Choi et al.
BIOMOLECULES & THERAPEUTICS (2015)
Cafestol-Type Diterpenoids from the Twigs of Tricalysia fruticosa with Potential Anti-inflammatory Activity
Chuan-Pu Shen et al.
JOURNAL OF NATURAL PRODUCTS (2015)
Cafestol, a Bioactive Substance in Coffee, Stimulates Insulin Secretion and Increases Glucose Uptake in Muscle Cells: Studies in Vitro
Fredrik Brustad Mellbye et al.
JOURNAL OF NATURAL PRODUCTS (2015)
Effect of the coffee ingredient cafestol on head and neck squamous cell carcinoma cell lines
Ulana Kotowski et al.
STRAHLENTHERAPIE UND ONKOLOGIE (2015)
Insights on the antitumor effects of kahweol on human breast cancer: Decreased survival and increased production of reactive oxygen species and cytotoxicity
Casimiro Cardenas et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)
Long-Term Coffee Consumption and Risk of Cardiovascular Disease A Systematic Review and a Dose-Response Meta-Analysis of Prospective Cohort Studies
Ming Ding et al.
CIRCULATION (2014)
Coffee components and cardiovascular risk: beneficial and detrimental effects
Justyna Godos et al.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION (2014)
Anti-Proliferative Properties of Kahweol in Oral Squamous Cancer Through the Regulation Specificity Protein 1
Jung-Il Chae et al.
PHYTOTHERAPY RESEARCH (2014)
Urotensin II Induces Interleukin 8 Expression in Human Umbilical Vein Endothelial Cells
Chung-Yi Lee et al.
PLOS ONE (2014)
Cafestol overcomes ABT-737 resistance in Mcl-1-overexpressed renal carcinoma Caki cells through downregulation of Mcl-1 expression and upregulation of Bim expression
S. M. Woo et al.
CELL DEATH & DISEASE (2014)
Coffee: biochemistry and potential impact on health
Iziar A. Ludwig et al.
FOOD & FUNCTION (2014)
Antiangiogenic properties of cafestol, a coffee diterpene, in human umbilical vein endothelial cells
Shuaiyu Wang et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)
The Coffee Diterpene Kahweol Prevents Osteoclastogenesis via Impairment of NFATc1 Expression and Blocking of Erk Phosphorylation
Reiko Fumimoto et al.
JOURNAL OF PHARMACOLOGICAL SCIENCES (2012)
Natural diterpenes from coffee, cafestol and kahweol induce apoptosis through regulation of specificity protein 1 expression in human malignant pleural mesothelioma
Kyung-Ae Lee et al.
JOURNAL OF BIOMEDICAL SCIENCE (2012)
Cafestol, a coffee-specific diterpene, induces apoptosis in renal carcinoma Caki cells through down-regulation of anti-apoptotic proteins and Akt phosphorylation
Min Jung Choi et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2011)
Correction: Anti-Angiogenic and Anti-Inflammatory Properties of Kahweol, a Coffee Diterpene
Casimiro Cárdenas et al.
PLoS One (2011)
Urotensin-II-stimulated expression of pro-angiogenic factors in human vascular endothelial cells
Giovanna Albertin et al.
REGULATORY PEPTIDES (2011)
Cafestol, a Coffee-Specific Diterpene, Is a Novel Extracellular Signal-Regulated Kinase Inhibitor with AP-1-Targeted Inhibition of Prostaglandin E-2 Production in Lipopolysaccharide-Activated Macrophages
Ting Shen et al.
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2010)
Nuclear Factor-κB/Signal Transducers and Activators of Transcription-1-Mediated Inflammatory Responses in Lipopolysaccharide-Activated Macrophages Are a Major Inhibitory Target of Kahweol, a Coffee Diterpene
Ting Shen et al.
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2010)
The coffee diterpene kahweol sensitizes TRAIL-induced apoptosis in renal carcinoma Caki cells through down-regulation of Bcl-2 and c-FLIP
Hee Jung Um et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2010)
Absorption, Distribution, and Biliary Excretion of Cafestol, a Potent Cholesterol-Elevating Compound in Unfiltered Coffees, in Mice
S. T. J. van Cruchten et al.
DRUG METABOLISM AND DISPOSITION (2010)
The role of epoxidation and electrophile-responsive element-regulated gene transcription in the potentially beneficial and harmful effects of the coffee components cafestol and kahweol
Saskia T. J. van Cruchten et al.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2010)
The coffee diterpene kahweol induces apoptosis in human leukemia U937 cells through down-regulation of Akt phosphorylation and activation of JNK
Jung Hwa Oh et al.
APOPTOSIS (2009)
Local communication on and within bone controls bone remodeling
Kim Henriksen et al.
BONE (2009)
AMPK: An Emerging Drug Target for Diabetes and the Metabolic Syndrome
Bei B. Zhang et al.
CELL METABOLISM (2009)
Differential Reactivity of Purified Bioactive Coffee Furans, Cafestol and Kahweol, with Acidic Nitrite: Product Characterization and Factors Controlling Nitrosation Versus Ring-Opening Pathways
Maria De Lucia et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2009)
Kahweol blocks STAT3 phosphorylation and induces apoptosis in human lung adenocarcinoma A549 cells
Hyung Gyun Kim et al.
TOXICOLOGY LETTERS (2009)
Effects of coffee and its chemopreventive components kahweol and cafestol on cytochrome P450 and sulfotransferase in rat liver
Wolfgang W. Huber et al.
FOOD AND CHEMICAL TOXICOLOGY (2008)
The multifaceted mechanisms for coffee's anti-tumorigenic effect on liver
Kai-Shain Tao et al.
MEDICAL HYPOTHESES (2008)
Induction of cancer chemopreventive enzymes by coffee is mediated by transcription factor Nrf2. Evidence that the coffee-specific diterpenes cafestol and kahweol confer protection against acrolein
Larry G. Higgins et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2008)
Hepatoprotective and antioxidant effects of the coffee diterpenes kahweol and cafestol on carbon tetrachloride-induced liver damage in mice
Kyung Jin Lee et al.
FOOD AND CHEMICAL TOXICOLOGY (2007)
The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane X receptors
Marie-Louise Ricketts et al.
MOLECULAR ENDOCRINOLOGY (2007)
Activating transcription factor 3, a stress-inducible gene, suppresses Ras-stimulated tumorigenesis
D Lu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Inhibitory effect of the coffee diterpene kahweol on carrageenan-induced inflammation in rats
JY Kim et al.
BIOFACTORS (2006)
Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination
CH Yan et al.
EMBO JOURNAL (2005)
Nitric oxide inhibits matrix metalloproteinase-2 expression via the induction of activating transcription factor 3 in endothelial cells
HH Chen et al.
MOLECULAR PHARMACOLOGY (2004)
The coffee diterpene kahweol suppress the inducible nitric oxide synthase expression in macrophages
JY Kim et al.
CANCER LETTERS (2004)
Suppressive effects of the kahweol and cafestol on cyclooxygenase-2 expression in macrophages
JY Kim et al.
FEBS LETTERS (2004)
Potential chemoprotective effects of the coffee components kahweol and cafestol palmitates via modification of hepatic N-acetyltransferase and glutathione S-transferase activities
WW Huber et al.
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS (2004)
The biology of VEGF and its receptors
N Ferrara et al.
NATURE MEDICINE (2003)
Coffee and its chemopreventive components Kahweol and Cafestol increase the activity of O6-methylguanine-DNA methyltransferase in rat liver -: comparison with phase II xenobiotic metabolism
WW Huber et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2003)
Cafestol and kahweol, two coffee specific diterpenes with anticarcinogenic activity
C Cavin et al.
FOOD AND CHEMICAL TOXICOLOGY (2002)
Effect of ethanol treatment on metabolic activation and detoxification of esophagus carcinogenic N-nitrosamines in rat liver
Y Mori et al.
MUTAGENESIS (2002)
Enhancement of the chemoprotective enzymes glucuronosyl transferase and glutathione transferase in specific organs of the rat by the coffee components kahweol and cafestol
WW Huber et al.
ARCHIVES OF TOXICOLOGY (2002)
The coffee components kahweol and cafestol induce gamma-glutamylcysteine synthetase, the rate limiting enzyme of chemoprotective glutathione synthesis, in several organs of the rat
WW Huber et al.
ARCHIVES OF TOXICOLOGY (2002)
Sp1 and kruppel-like factor family of transcription factors in cell growth regulation and cancer
AR Black et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2001)
Consumption of French-press coffee raises cholesteryl ester transfer protein activity levels before LDL cholesterol in normolipidaemic subjects
B De Roos et al.
JOURNAL OF INTERNAL MEDICINE (2000)
Cafestol increases serum cholesterol levels in apolipoprotein E*3-Leiden transgenic mice by suppression of bile acid synthesis
SM Post et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2000)