期刊
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
卷 442, 期 -, 页码 44-50出版社
ELSEVIER
DOI: 10.1016/j.ijms.2019.05.004
关键词
Nitrogen-doped carbon dots; Matrix; Citric acid; Urea; MALDI-MS
资金
- Basic Science Research Program through the National Research Foundation of Korea - Ministry of Education [2016R1D1A1B02008854]
- National Research Foundation of Korea [2016R1D1A1B02008854] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Nitrogen-doped carbon dots (N-CDs) were synthesized by microwave-assisted pyrolysis of citric acid and urea for use as an alternative matrix for the detection of small molecules using matrix-assisted laser desorption/ionization spectrometry (MALDI-MS). The synthesis of N-CDs is much simpler than that of other nitrogen-doped carbon matrices used in MALDI-MS, which has been a major limitation to its application. The synthesized N-CDs were characterized using various analytical methods. The high optical absorbance and good dispersibility of the obtained N-CDs showed them to be an ideal matrix for detecting analytes such as glucose, sucrose, amino acids, nilotinib, and polyethylene glycols. The application of N-CDs as a MALDI matrix improved the signal response of small molecules due to the specific aromatic structure and the doping of nitrogen atoms. The minimum detectable amounts using an N-CDs matrix in MALDI-MS were found to be in the range of 1 nmol-1 pmol, with a lower minimum detectable amount of arginine (1 pmol) than previously reported. (C) 2019 Elsevier B.V. All rights reserved.
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