期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 135, 期 -, 页码 233-239出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2019.05.145
关键词
Chitosan-TiO2; Layer-by-layer; Electrospraying; Nanofibers; Antibacterial applications
资金
- National Key R&D Program of China [2016YFB0303303]
- Natural Science Foundation of Hubei Province of China [2015CFA017]
- Fundamental Research Funds for the Central Universities of China [2042017kf0175]
The antibacterial materials with biodegradable and biocompatible nature have unveiled novel prospects to combat the bacterial infection, which has always been a troubling and challenging issue in the biomedical field. In this study, chitosan (CS) and Titanium dioxide (TiO2) micropartides were well immobilized on polylactic acid (PLA) mats by electrospinning-electrospraying hybrid technique. The surface morphology, chemical composition and characteristic group of the mats were characterized. The results indicated that CS/TiO2 microparticles were successfully immobilized on the surface of PLA mats. In addition, the antibacterial activity and cytotoxicity of the composite mats were investigated to confirm that the layer-by-layer immobilization of CS/TiO2 microparticles via electrospraying could enhance the antibacterial effect and biocompatibility of the mats. At the same time, the PLA-(CS/TiO2-1.5%)1.5 mats exhibited the best performance in antibacterial effect (up to about 95%) and cell viability (nearly 92% and 95% at 3 d and 5 d). The composite mats have great potential as an effective antibacterial material for the biomedical applications. (C) 2019 Published by Elsevier B.V.
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