期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 134, 期 -, 页码 759-769出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2019.05.070
关键词
Seaweed; Reverse cholesterol transport; Lipid-lowering; ABC transporter; High-fat diet
资金
- National Natural Science Foundation of China [81770463, 31300639]
- Natural Science Foundation of Shandong Province [ZR2013HQ014]
- Natural Science Foundation of Heilongjiang Province [H2015088]
- Innovation Talents Project of Harbin Science and Technology Bureau [2016RQYXJ014]
- Science Foundation Project of Harbin University of Commerce [18XN067]
Reverse cholesterol transport (RCT) has been demonstrated to reduce hyperlipidemia, and fucoidans are found to possess hypolipidemic effect. This study was designed to investigate the lipid-lowering effect of the fucoidan from the brown seaweed A. nodosum and whether it improves RCT-related genes expression in C57 BL/6J mice. Our results indicated that fucoidan A3 (100 mg/kg/day) intervention significantly reduced plasma total cholesterol (similar to 23.2%), triglyceride (similar to 48.7%) and fat pad index. This fucoidan significantly increased the mRNA expression of low-density lipoprotein receptor (LDLR), scavenger receptor B type 1 (SR-B1), cholesterol 7 alpha-hydroxylase A1 (CYP7A1), liver X receptor (LXR) beta, ATP-binding cassette transporter (ABC) A1 and sterol regulatory element-binding protein (SREBP) 1c, and decreased the expression of peroxisome proliferator-activated receptor (PPAR) gamma however, it had no effect on the expression of proprotein convertase subtilisin/kexin type 9, PPAR alpha, LXR alpha, SREBP-2, ABCG1, ABCG8 and Niemann-Pick C1-like 1. These results demonstrated that this fucoidan improved lipid transfer from plasma to the liver by activating SR-B1 and LDLR, and up-regulated lipid metabolism by activating LXR beta, ABCA1 and CYP7A1. In conclusion, this fucoidan lowers lipid by enhancing RCT-related genes expression, and it can be explored as a potential candidate for prevention or treatment of lipid disorders. (C) 2019 Published by Elsevier B.V.
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