期刊
INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH
卷 53, 期 4, 页码 724-732出版社
ASSOC PHARMACEUTICAL TEACHERS INDIA
DOI: 10.5530/ijper.53.4.137
关键词
Moxifloxacin; HCI; Gastroretentive; Bio adhesion; HPMCK100M; Lannea coromandelica gum; Swelling Study
Objective: The purpose of present research work is to develop gastro retentive formulation for Moxifloxacin using various drug release modifiers. Moxifloxacin, novel synthetic fluoro quinolone, antibacterial agent. Methods: SR granules were prepared by gastro retentive tablets of Moxifloxacin. HCI were prepared using variable amounts of HPMCK100M, Lannea coromandelica gum (LCG) by moist granulation technique. Totally 10 SR granule formulations were prepared and subjected to precompression analysis and drug release profiles. Based on the results screening of concentrations for polymers and are used for Tablet formulations. Six tablet formulations were designed and are evaluated for various pharmacopoeial tests. Drug release profiles of formulation trails subjected to kinetic modeling. a,b,r were determined. Results: The results reveals that retention time decreases with decreased viscosity of polymer. F16 prepared with LCG was found to have highest swelling property. High bioadhesive strength of the formulation is likely to increase its GI residence time. Lannea coromandelica gum powder needs to explored as a sustain release material at commercial scale.
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