期刊
IET NANOBIOTECHNOLOGY
卷 13, 期 8, 页码 880-886出版社
INST ENGINEERING TECHNOLOGY-IET
DOI: 10.1049/iet-nbt.2019.0144
关键词
hydrogen bonds; selenium; nanoparticles; solubility; drug delivery systems; toxicology; hydrophobicity; free radicals; particle size; nanofabrication; cancer; nanomedicine; drugs; biomedical materials; encapsulation; cellular biophysics; pH; organic compounds; pectin-decorated selenium nanoparticles; pectin-stabilised selenium nanoparticles; curcumin encapsulation; Cur-loaded pectin-SeNPs; nanocarrier pectin-SeNPs; physicochemical properties; biological properties; homogeneous spherical structures; monodisperse spherical structures; aqueous solutions; particle size; hydrogen bonding interactions; encapsulation efficiency; loading content; pH-dependent drug release; in vitro controlled drug release; water solubility; free radical scavenging ability; in vitro antioxidant capacity; in vitro antitumour activity assay; HepG2 cells; cytotoxic activity; in vitro bioactivity; hydrophobic curcumin; Se
资金
- National Science Foundation of China [U1604176]
- Program for Innovative Research Team (in Science and Technology) in University of Henan Province [20IRTSTHN022]
In this study, the authors developed pectin-stabilised selenium nanoparticles (pectin-SeNPs) for curcumin (Cur) encapsulation and evaluated their physicochemical properties and biological activities. Results showed that pectin-SeNPs and Cur-loaded pectin-SeNPs (pectin-SeNPs@Cur) exhibited monodisperse and homogeneous spherical structures in aqueous solutions with mean particle sizes of similar to 61 and similar to 119 nm, respectively. Cur was successfully encapsulated into pectin-SeNPs through hydrogen bonding interactions with an encapsulation efficiency of similar to 60.6%, a loading content of similar to 7.4%, and a pH-dependent and controlled drug release in vitro. After encapsulation was completed, pectin-SeNPs@Cur showed enhanced water solubility (similar to 500-fold), dispersibility, and storage stability compared with those of free Cur. Moreover, pectin-SeNPs@Cur possessed significant free radical scavenging ability and antioxidant capacity in vitro, which were stronger than those of pectin-SeNPs. Antitumour activity assay in vitro demonstrated that pectin-SeNPs@Cur could inhibit the growth of HepG2 cells in a concentration-dependent manner, and the nanocarrier pectin-SeNPs exhibited a low cytotoxic activity against HepG2 cells. Therefore, the results suggested that pectin-SeNPs could function as effective nanovectors for the enhancement of the water solubility, stability, and in vitro bioactivities of hydrophobic Cur.
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