期刊
IET NANOBIOTECHNOLOGY
卷 13, 期 9, 页码 967-973出版社
WILEY
DOI: 10.1049/iet-nbt.2019.0038
关键词
nanoparticles; molecular biophysics; silver; liver; nanofabrication; microorganisms; petroleum; biotechnology; antibacterial activity; surfactants; cellular biophysics; toxicology; surface tension; nanomedicine; Fourier transform infrared spectra; C-H functional groups; bending; synthesised AgNPs; excellent antimicrobial activities; ATCC no; bacillus subtilis; antimicrobial activity; silver nanoparticles; bacillus vallismortis MDU6 strain; microbial biosurfactants; green molecules; chemical diversity; environmental sectors; industrial sectors; pharmaceutical sector; noncytotoxic activities; petroleum oil; soil sample; isolate; surface tension; crude biosurfactant show; asymmetric stretching; symmetric stretching; Genbank accession no; MH382951; time 5; 0 d; Ag
资金
- DST-SERB [PDF/2016/002038, BT/BI/13/035/2017]
Microbial biosurfactants has evolved as green molecules and their chemical diversity has gained momentum in recent time not only in the field of environmental and industrial sectors but also in the pharmaceutical sector. In this study, an effort was made for the biosynthesis of silver nanoparticle (AgNPs) having antimicrobial and non-cytotoxic activities with the help of microbial biosurfactant extracted from a novel Bacillus vallismortis strain MDU6 (Genbank accession no. MH382951) from petroleum oil logged soil sample in Dibrugarh, Assam. The isolate shows excellent potential for the production of biosurfactant by reducing the surface tension of diesel supplemented medium up to 56.57% only within 5 days. FTIR spectra of the crude biosurfactant show the presence of v(CH2) (asymmetric stretching), v(CH2) (symmetric stretching), v(C=C) (stretch), v(C-C) (stretch), v(C-H) (bending), v(C-O) (stretch) and v(C-H) (bending) functional groups and LC-MS/MS analysis confirms it as a cyclic lipopeptide which is a mixture of surfactin and iturin. The synthesized AgNPs showed excellent antimicrobial activities against Escherichia coli (ATCC no. 25922), Listeria monocytogenes (ATCC No. BAA-751), Staphylococcus aureus (ATCC No. 9542) and Bacillus subtilis (ATCC no. 6051) and showed no cytotoxicity against primary mouse liver cell lines.
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