期刊
ATHEROSCLEROSIS
卷 248, 期 -, 页码 245-251出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2016.02.013
关键词
Vascular stiffness; Endothelial function; Biomarkers; ST2; GDF-15; Troponin I; General population
资金
- NIH Heart, Lung and Blood Institute [N01-HC-25195, R01 HL107385, 1R01HL60040, 1RO1HL70100]
- Evans Scholar award from department of Medicine, Boston University School of Medicine
- Desanctis Clinical Scholar Endowment
- Hutter Family Professorship
- Danish Research Council
Background and aims: Growth differentiation factor-15 (GDF-15), soluble (s) ST2, and high-sensitivity troponin-I (hs-TnI) are associated with incident cardiovascular disease (CVD) including heart failure, yet the underlying mechanisms are not fully understood. We investigated if GDF-15, sST2, and hs-TnI are related to subclinical vascular dysfunction in the community, which may explain the relations of these biomarkers with CVD. Methods: We evaluated 1823 Framingham Study participants (mean age 61 +/- 10 years, 54% women) who underwent routine assessment of vascular function. We related circulating GDF-15, sST2, and hs-TnI concentrations to measures of arterial stiffness (carotid-femoral pulse wave velocity, CFPWV; augmentation index; and forward pressure wave amplitude, FW), endothelial-dependent vasodilation (flow-mediated dilation, FMD), and baseline and hyperemic brachial flow velocities using linear regression adjusting for standard risk factors. Results: After multivariable adjustment, GDF-15 levels were positively associated with CFPWV (0.044 [95% confidence interval 0.007-0.081] standard deviation [SD] change per SD increase in log(e)[GDF-15], p = 0.02) and FW (0.076 [0.026-0.126] SD change per SD increase in log(e)[GDF-15], p = 0.003) and inversely related to FMD (-0.051 [-0.101-0.0003] SD change per SD increase in log(e)[GDF-15], p = 0.048). sST2 was positively associated with CFPWV (0.032 [0.0005-0.063] SD change per SD increase in log(e)[sST2], p = 0.046), and hs-TnI inversely associated with hyperemic flow velocity (-0.041 [-0.082 -0.0004] SD change per SD increase in log(e)[hs-TnI], p = 0.048). Conclusion: In our community-based investigation, individual cardiac stress biomarkers were differentially related to select aspects of vascular function. These findings may contribute to the associations of circulating GDF-15, sST2, and hs-TnI with incident CVD and heart failure. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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