期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 25, 期 4, 页码 753-757出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2015.01.006
关键词
Quasi push-pull; Dibenzodioxins; Internal charge transfer; Solvatochromism; Cell viability
资金
- Birla Institute of Technology and Science-Pilani, K.K. Birla Goa Campus
Dibenzodioxins bearing multiple electron withdrawing groups were synthesized using a simple one-step methodology including examples of molecules possessing electron acceptor groups in both ends. As a consequence internal charge delocalization occurs and the optical spectra are found to be bathochromi-cally shifted compared to similar examples known thus far. A theoretical analysis of the molecular orbitals reveals the origin of the peaks in the dibenzodioxin optical spectra. Select examples exhibit in vitro neuro-cytotoxicity against glioma cell line C6, a finding which enhances existing knowledge about the pharmacologically relevant structural motifs in dibenzodioxins. (C) 2015 Elsevier Ltd. All rights reserved.
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